美国德州西南医学中心蔡昕实验室现诚聘研究生和博士后。我们实验室主要致力于癌症代谢和先天免疫信号通路的研究。代谢产物的起源和去向的代谢途径，以及它们在癌症或其他疾病中已知的代谢功能，已经有一个多世纪的研究历史。我们提出，独立于这些已知功能，代谢产物是细胞间通信至关重要的信号分子。我们期望深入探索代谢产物如何作为信号分子来调节信号传导，从而调节细胞的生理功能，包括细胞的增殖、分化以及对抗病原体感染的能力。我们与生物化学家和结构生物学家合作，开发新的方法来研究蛋白质-代谢产物和RNA-代谢产物之间的相互作用。网站: www.xincailab.comHow do metabolites function as signaling molecules independent of their metabolism?Metabolites often accumulate during diseases, including cancer, infection, and inflammation. As their names suggest, metabolites undergo enzyme-mediated chemical reactions, which have been studied for over a century. While most studies have focused on their known metabolic functions in cancer and other diseases, we propose that, independent of these functions, metabolites are critical signaling molecules essential for cell-cell communication. Using questions guided by human clinical observations from patients, we conduct hypothesis-driven research through a combination of in vitro and in vivo models. We collaborate with biochemists and structural biologists to develop new methods to study protein-metabolite and RNA-metabolite interactions. Postdoc candidates with expertise in chemistry, biochemistry, RNA biology or cell and molecular biology are encouraged to apply by emailing xin.cai@utsouthwestern.edu with the following attachments: 3)Names and contact info for 3 references.Bibliography 1.Cai et al. Molecular Cell. 83 (21): 3904-20 (2023)2.Cai et al. Cell. 156 (6): 1207-1222 (2014)3.Cai et al. Molecular Cell. 54 (2): 289-296 (2014)4.Cai et al. Cold Spring Harbor Perspect Biol. 9 (4). a023580 (2017)5.Cai et al. Trends in Immunology. 35 (12): 622-630 (2014) | 
