美国威斯康星大学麦迪逊分校（University of Wisconsin-Madison），简称UW-Madison，创建于1848年，位于美国威斯康星州首府麦迪逊，是一所世界顶尖的著名公立研究型大学，位列2023软科世界大学学术排名第32位，2023 U.S. News世界大学排名第35位。威斯康星大学麦迪逊分校是美国大学协会和十大联盟创始成员（Big Ten），被誉为公立常春藤大学，其药学院全美排名第七 （US news 2023）。药学院Dr. Ting Fu lab招收博士研究生2名，博士后1名。威斯康星州首府麦迪逊市，环境优美，治安良好，被评为全美十大最适宜居住的城市之一。1.实验室以及PI介绍：Dr. Ting Fu 在伊利诺伊大学厄巴纳-香槟分校 (UIUC)的Prof. Jongsook Kim Kemper 实验室进行博士研究并取得博士学位，之后在索尔克研究所（Salk Institute）享有国际声誉的核受体之父Prof. Ronald Evans实验室进行博士后研究。博士和博士后研究方向都围绕胆汁酸及其核受体FXR进行，博士期间主要集中于肥胖症，糖尿病以及脂肪肝等代谢类疾病的研究；博后期间主要集中于肠癌，肠炎以及肠道微生物的研究。博士博后期间在Nature，Cell，PNAS，Cell Report, MCB 等杂志发表多篇第一作者研究成果， 亦有合作发表多篇Nature， Cell Metabolism，Aging cell，Cancer Cell 等系列研究文章以及综述文章。2.研究方向: Fu lab将继续围绕核受体以及胆汁酸研究肠道生理代谢，炎症癌症，以及肠道微生物和其修饰产生的新型胆汁酸的研究中，并聚焦于研发新的小分子化合物（small－molecular therapy）， 免疫调节 （immunomodulators）和肠道微生物相关的治疗和诊断。实验室会利用药物药理工具（pharmacological tools），基因敲除小鼠(genetic tools) ，以及人鼠3D小肠细胞（organoids，PDCOs），黏膜免疫，宿主及微生物组测序等一系列平台和技术去研究肠炎肠癌。更多详情请见：https://apps.pharmacy.wisc.edu/sopdir/ting_fu/index.phphttps://scholar.google.com/citations?hl=en&user=Xgj_zLsAAAAJ&view_op=list_works&sortby=pubdate1）博士生职位：鼓励具有分子生物学，细胞生物学，免疫学，人体和动物医学生理学，微生物学等相关背景的本科生或硕士生申请，具有一定研究经验者会优先考虑。GPA至少高于3，3.2 以上优先考虑。具有良好的英文读写和沟通能力，不需要GRE成绩，TOEFL 成绩（高于95，100以上优先考虑） 或者 IELTS成绩（高于6.5，7以上优先考虑）。希望申请者具有良好的科学素养，严谨学术态度，敬业精神，团队合作意识和沟通协调能力。https://pharmacy.wisc.edu/pharmsci/phd-program/https://molpharm.wisc.edu/2) 博士后职位：鼓励具有分子生物学，细胞生物学，免疫学，人体和动物医学生理学，微生物学等相关背景的博士生申请，具有良好的英文读写和沟通能力，并具有独立思考能力，良好的科学素养，严谨学术态度，敬业精神，团队合作意识和沟通协调能力。欢迎感兴趣的同学老师咨询和申请，请将相关申请材料发送至ting.fu@wisc.edu。博士后职位：请将Cover Letter和CV合并成一个PDF文件发送至Dr. Fu邮箱，在标题中注明postdoc or ph.D application，请在Cover Letter中简述您的研究成果。被录用的博士后和博士生将享有University of Wisconsin-Madison的统一待遇和福利，并享受各类研究学习资源。1.Xingchen Dong, Fei Sun, …, Ting Fu #. The dichotomous roles of microbial modified bile acids, 7-oxo-Deoxycholic Acid and Iso-Deoxycholic Acid in intestinal tumorigenesis (under revision in PNAS).2.Xingchen Dong#, Chunmiao Cai, Yu Zhu, Sally Coulter, Christopher Liddle, Nataliya V Uboha, Richard Halberg, Wei Xu, Paul Marker, Ting Fu#.FXR mediates macrophage-intrinsic responses to suppress colitis-induced colon cancer progression. Journal of Clinical Investigation Insight . DOI: 10.1172/jci.insight.170428. #, co-first authorship. *, corresponding authorship.3.Young-Chae Kim, Sunmi Seok, Xingchen Dong, Hao Sun, Byron Kemper, Ting Fu*, Jongsook Kim Kemper*. Impaired phosphorylation of SHP by FGF15/19 alters bile acids and gut bacteria, promoting nonalcoholic fatty liver disease. Journal Biological Chemistry, 2023. DOI:10.1016/j.jbc.2023.104946 PubMed PMID: 37348559 *,co-corresponding authorship.4.Xingchen Dong#, Chunmiao Cai#, Ting Fu . FXR suppress colorectal cancer by inhibiting the Wnt/β-catenin pathway via activation of TLE3. Genes and Diseases, 2022. DOIhttps://doi.org/10.1016/j.gendis.2022.09.006: 10.1016/j.gendis.2022.09.006 5.Ting Fu#, Tao Huan#, Gibraan Rahman#, Hui Zhi, …, Manuela Raffatellu, Pieter C. Dorrestein, Michael Downes, Rob Knight*, Ronald M. Evans*. Paired microbiome and metabolome analyses associate bile acid changes with colorectal cancer progression. Cell Reports. 2023 Aug;112997. DOI: 10.1016/j.celrep.2023.112997. PubMed PMID: 37611587. (*, co-corresponding authorship. #, co-first authorship)6.Ting Fu, Yuwenbin Li, Tae Gyu Oh, Fritz Cayabyab, ...,Ye Zheng, Christopher Liddle, MichaelDownes*, Ronald M. Evans*, et al. FXR mediates ILC-intrinsic responses to intestinal inflammation. Dec 12, 2022, PNAS. DOI: doi/10.1073/pnas.2213041119.7.Ting Fu, Sally Coulter, Eiji Yoshihara, Tae Gyu Oh, Sungsoon Fang, Fritz Cayabyab, Qiyun Zhu,Michael Downes*, Ronald M. Evans*, et al. FXR regulates intestinal stem cell proliferation. VOLUME176, ISSUE 5, P1098-1112.E18, FEBRUARY 21, 2019, Cell. DOI: https://doi.org/10.1016/j.cell.2019.01.0368.Robert A. Quinn, Alexey V. Melnik, Alison Vrbanac, Ting Fu, …Ronald M. Evans, Victor Nizet, Rob Knight, and Pieter C. Dorrestein, et al. Global Chemical Impacts of the Microbiome Include Unique Bile Acid Conjugates that Stimulate FXR. Nature, 2020 Mar; 579(7797):123-129.9.Ting Fu*, Youngchea Kim*, Dong-Hyun Kim, Sunmi Seok, Kelly Suino-Powell, H. Eric Xu, Byron Kemper and Jongsook Kim Kemper. FXR primes the liver for intestinal FGF15 signaling by transient induction of βklotho. Molecular Endocrinology, 2015 Oct 23; DOI: http://dx.doi.org/10.1210/me.2015-122610.Sunmi Seok*, Ting Fu*, Sung-E Choi, Yang Li, Rong Zhu, Subodh Kumar, Xiaoxiao Sun, Gyesoon Yoon, Yup Kang, Wenxuan Zhong, Jian Ma, Byron Kemper, and Jongsook Kim Kemper. Transcriptional regulation of autophagy by an FXR/CREB1 axis. axis (*equal contribution to this work) Nature, 516, 108–111, 2014. (04 December 2014) DOI: 10.1038/nature1394911.Ting Fu, Sunmi Seok, Sung-E Choi, Zhang Huang, Kelly Suino-Powell, H. Eric Xu, Byron Kemper, and Jongsook Kim Kemper. MiR-34a inhibits beige and brown fat formation in obesity in part by suppressing adipocyte FGF21 signaling and SIRT1 function. Molecular and Cellular Biology, 2014, Nov 15; 34(22):4130-42. 12.Ting Fu, SungE Choi, Dong-Hyun Kim, Sunmi Seok, Kelly Suino-Powell, H. Eric Xu, and Jongsook Kim Kemper. Aberrantly elevated miR-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor β-Klotho. PNAS, 2012 Oct 2; 109(40):16137-42.https://scholar.google.com/citations?user=Xgj_zLsAAAAJ&hl=enSelected Fellowship and Awards:2024-2030 NCI MERIT Award (R37)2024 Faculty Starter Grant Award, PhRMA Foundation2024-2025 Early stage Investiagtor Award, Margaret Q. Landenberger Research Foundation2023-2027 Research Scholar Grant, American Cancer Society (ACS) – Coaches vs. Cancer – Bo Ryan-Jay Holliday Families Fund2020 AACR Annual Meeting Scholar-in-Training Award2019 Crohn’s & Colitis Foundation (CCFA), Visiting Scholar Fellowship Award, U.S.2017-2019 Hewitt 3-Year Postdoc Fellowship Award, Hewitt foundation for Medical Research, CA, U.S.2017 Salk mini-grant, Nanostring technology Company2017 Early Career Investigator Travel Stipend Awards, Kern Lipid Conference, CO, U.S.2017 Franz Simon Poster Award, Kern Lipid Conference, CO, U.S.2016 Salk Alumni Fellowship Award, Salk Institute, La Jolla, CA, U.S.2015 Outstanding Ph.D. Thesis Award, MIP department, UIUC, Urbana, IL, U.S. |
